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Mildronate in UK is not sold in pharmacies but can be easily imported. United Kingdom is fairly close to countries where Mildronate is sold over the counter and has been used by population for over 4 decades! The closest country where it is sold in pharmacies without prescription is Latvia. There are few vendors which ship to UK from there and have no problems getting your desired Mildronate over the border. In fact it is allowed to ship over the counter medication with national post , it could change post Brexit but since packages containing Mildonate are small , it is unlikely that there will be any problems.
Mildronate is the most popular brand name of active substance Meldonium. Mildronate is manufactured by company ‘’Grindeks’’ and is considered a high quality medicine manufacturer in Latvia. It produces everything from supplements, over the counter pain meds to antidepressants.
Mildronate historically is made in 2 forms 250mg 20 capsules and 500 mg 60 capsules. The packaging is undergoing some changes in the last few months of year 2020, the historic 20 capsule 250mg (yellow) pack is slowly being replaced by 250mg N40 package in pink color ( see the picture below) .
The dosage is pretty straight forward. Start small and increase slowly your dosage. 250mg per day in the mornings for few days to weeks, if this does not work, increase it to 500mg and so on. Usually it is taken in mornings because it can give you extra energy and you don’t want that in night. For medical conditions doctors tend to dosage of 2x 500mg a day. This is also why the 500mg package contains 60 caps, it gives you exactly one month supply. Also they prescribe it for few months and then advice to stop for month or two to assess the impact. There has been reports of athletes taking as high as 2000mg per day. In any case it is better to consult a doctor before any supplements or medication use.
They also manufacture Meldonium in injections and sell it in 10% 5ML N10 and N20 packages, those who prefer injections can use it in this form. This could be trickier to get hold of and transport because of glass ampoules inside the packages.
Combat fatigue, including chronic fatigue syndrome and post viral syndrome.
To increase brain function.
To improve work ability.
Recover from stressful life events.
In some cases before and after surgery.
Treatment of heart ischemia and its consequences
Increase stamina and strength.
Recovery after infectious diseases like flu.
Treatment of diabetes.
Treatment of Alzheimer’s disease.
Meldonium given in acute doses could be beneficial for the treatment of seizures and alcohol intoxication.
In short Mildronate in UK or any other countries are used for many different conditions and life situations. From students trying to get thru their stressful study semester to people with serious heart conditions. It even has been suggested as treatment for infertility in men , because of research showing improved sperm activity in boars. The Sharapova scandal which shined light to this substance around the globe including UK, had a positive and negative impact on the Meldonium. Negative that it was named a doping and therefore some think that it is something harmful like other hard doping substances , which is not the case. The positive impact was that it had huge coverage around the globe and many found out about this potentially great OTC medication.
Grindeks is expanding their Mildronate markets constantly, they are pursuing Turkish and other markets but unfortunately there has not been much information about expanding in new markets in Europe. If the Brexit talks fall through then it is even less likely that you will be able to see Mildronate in UK’s pharmacies in year 2021.
Mildronate is thought to expand the arteries, it helps to increase the blood flow as well as increase the flow of oxygen throughout the body. But the mechanism behind meldonium workings is quite complicated, I will try to explain it with leaving out most of the scientific stuff.
The story starts with a thing called Carnite, Carnitine plays a pivotal role in transportation of fatty acids and other products of oxidation to the mitochondria. Mitochondria is often called the powerhouse of the cell.
Four enzymes are involved in manufacture of carnite, one of them has terribly long and almost unpronounceable name ‘’ gamma-butyrobetaine dioxygenase’’, lets call it GBB. By slowing down the production of GBB, carnite production is slowed down as well. Mildronate does exactly that, it slows down the production of GBB.
So if manufacture of enzyme GBB is slowed down , then fatty acid transport is reduced which in turn leads to reduced accumulation of cytotoxic products in ischemic tissues. Which is the main cardio protective effect of this whole process. Also by blocking this process, oxygen is saved, because fatty acid oxidation consumes a lot of oxygen. This means that Mildronate shifts energy metabolism from fatty acid to oxidation to glucose. This is possible why athletes and people get more energy, stamina and better concentration from using Mildronate, their bodies have more free oxygen.
Even more it is believed that Meldonium trains the heart without doing exercise! Because it is adopting heart cells to reduce fatty acid inflow, this way heart slowly starts using more glycose. This process reduces oxidative stress and cell damage